We have several publications related to our patented technology. These include preclinical studies in both small and large animals.

Bengur FB, Komatsu C, Fedor CN, Loder S, Baker JS, Totwani A, Irgebay Z, Nerone WV, Solari MG, Marra KG. Biodegradable Nerve Guide with Glial Cell Line-Derived Neurotrophic Factor Improves Recovery After Facial Nerve Injury in Rats. Facial Plast Surg Aesthet Med. 2023 Mar 6. doi: 10.1089/fpsam.2022.0346. Epub ahead of print. PMID: 36877591.

Bengur FB, Stoy C, Binko MA, Nerone WV, Fedor CN, Solari MG, Marra KG. “Facial Nerve Repair: Bioengineering Approaches in Preclinical Models.” Tissue Eng Part B Rev. 2022 Apr;28(2):364-378. doi: 10.1089/ten.TEB.2020.0381

Fadia, N.B.; Bliley, J.M.; DiBernardo, G.A.; Crammond, D.J.; Schilling, B.K.; Sivak, W.N.; Spiess, A.M.; Washington, K.M.; Waldner, M.; Liao, H.-T.; James, I.B.; Minteer, D.M.; Tompkins-Rhoades, C.; Cottrill, A.R.; Kim, D.-Y.; Schweizer, R.; Bourne, D.A.; Panagis, G.E.; Schusterman II, M.A.; Egro, F.M.; Campwala, I.K.; Simpson, T.; Weber, D.J.; Gause II, T.; Brooker, J.E.; Josyula, T.; Guevara, A.A.; Repko, A.J.; Mahoney, C.M.; Marra, K.G.* “Long-Gap Peripheral Nerve Repair Through Sustained Release of a Neurotrophic Factor in Nonhuman Primates,” Science Translational Medicine. 2020;12(542):eabc4054. doi: 10.1126/scitranslmed.abc4054:



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Additional publications:

Bliley, J.M.; Sivak, W.N.; Minteer, D.M.; Tompkins-Rhoades, C.; Day, J.; Williamson, G.; Liao, H.T.; Marra, K.G.* “Ethylene Oxide Sterilization Preserves Bioactivity and Attenuates Burst Release of Encapsulated Glial Cell Line Derived Neurotrophic Factor from Tissue Engineered Nerve Guides For Long Gap Peripheral Nerve Repair,” ACS Biomaterials Science & Engineering, 2015, 1(7):504-512. DOI: 10.1021/ab5001518

Lin, Y.-C.; Oh, S.J.; Marra, K.G.* “Synergistic Lithium Chloride and Glial Cell Line-Derived Neurotrophic Factor Delivery for Peripheral Nerve Repair in a Rodent Sciatic Nerve Injury Model,” Plastic and Reconstructive Surgery, 2013, 132(2):251e-62e. PMID: 23897353 DOI: 10.1097/PRS.0b013e31829588cf

Kokai, L.E.; Bourbeau, D.; Weber, D.; McAtee, J.L.; Marra, K.G.* “Sustained Growth Factor Delivery Promotes Axonal Regeneration in Long Gap Peripheral Nerve Repair,” Tissue Engineering, Part A, 2011, 17(9-10):1263-75. PMID: 21189072 PMCID: PMC3079170

Kokai, L.E.; Ghaznavi, A.M.; Marra, K.G.* “Incorporation of Double-walled Microspheres into Polymer Nerve Guides for the Sustained Delivery of Glial Cell Line-derived Neurotrophic Factor,” Biomaterials, 2010, 31(8):2313-2322. PMID: 19969346 DOI: 10.1016/j.biomaterials.2009.11.075

Kokai, L.E.; Tan, H.; Jhunjhunwala, S.; Little, S.R.; Frank, J.; Marra, K.G.* “Protein Bioactivity and Polymer Orientation is Affected by Stabilizer Incorporation in Double-Walled Microspheres,” Journal of Controlled Release, 2010, 141:168-176. PMID: 19751780 DOI: 10.1016/j.jconrel.2009.09.003

Kokai, L.E.; Lin, Y.-C.; Oyster, N.O.; Marra, K.G.* “Diffusion of Soluble Factors through Degradable Polymer Nerve Guides: Controlling Manufacturing Parameters,” Acta Biomaterialia, 2009, 5:2540-2550. PMID: 19369123 DOI: 10.1016/j.actbio.2009.03.009

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